Her father was Rodrigo Flores de Valdez Carballo, and her mother was Maria Isabel de Salazar y Treviño.
She married Juan Martinez Guajardo, son of Juan Francisco Martinez Guajardo and Ursula Ines Catarina Navarro Rodriguez in 1622.
She married Diego Flores de Abrego, son of Pedro Flores and Melchora Gutierrez de Abrego. It was her second marriage.
Diego Flores de Abrego. He married Ana de Olarte. He married _ Martinez Guajardo.
Catalina Martinez. She had a relationship with Joseph Ramon (de Morales), son of Luis Morales and Juana de Treviño Quintanilla y Salazar.
Nicolas Martinez Guajardo. He married Maria de Aguirre, daughter of Capt. Pedro de Aguirre and Antonia Guillen.
Juan Martinez Guajardo. He married Clara de Aguirre, daughter of Capt. Pedro de Aguirre and Antonia Guillen.
Alonso Martinez Guajardo. In 1687, he requested a dispensation to marry Juana de la Cadena Vergara. He married Phelipa Muñoz y Serrano de Pamplona.
Isabel Flores Guajardo. She married Antonio Cortinas de Acosta.
Maria Guajardo. She married Bartolome de Cuellar.