Her father was Juan Martinez Guajardo, and her mother was Isabel Flores de Valdez.
She married Bartolome de Cuellar.
Ana de Lizarras y Cuellar. She married Juan de Arispe, son of Jose de Arispe and Leonor Gutierrez.
Maria de Cuellar. She married Alonso de la Peña.
Asencio de Cuellar. He married Ana Garcia, daughter of Mateo Garcia and Lucia de Treviño.