He married Antonia Guillen, daughter of Domingo Gonzalez and Maria de Abrego.

Maria de Aguirre. She married Nicolas Martinez Guajardo, son of Juan Martinez Guajardo and Isabel Flores de Valdez.

Clara de Aguirre. She married Juan Martinez Guajardo, son of Juan Martinez Guajardo and Isabel Flores de Valdez.

Ynes de Aguirre. She married Joseph de Farias, son of Lucas de Farias and Luisa Flores de Valdez.

Juan de Aguirre Guillen. In 1695, he requested a dispensation to marry Maria de Ayala Benavides, daughter of Juan Jose de Ayala and Ana Maria Baez de Benavides. He married Maria Gonzalez de Paredes, daughter of Juan Gonzalez and Maria de Olea Camacho. He married Juana Cortinas de Acosta, daughter of Antonio Cortinas de Acosta and Isabel Martinez. His wife died on 16 Oct 1735 in Saltillo. She was 85 years old.

Nicolas de Aguirre. He married Jacinta Gonzalez de Paredes, daughter of Juan Gonzalez and Maria de Olea Camacho.

Teresa de Aguirre. She married Miguel de Lizarras y Cuellar.

Margarita de Aguirre. She married Alonso Flores de Valdez, son of Alvaro Flores and Melchora Ramos de Arriola.

Jacinto de Aguirre. He married Ildefonsa Davila, daughter of Lorenzo Davila and Bernarda Flores Guajardo.

Pedro de Aguirre, born 1640. On 13 May 1683, he requested a dispensation to marry Maria Ramos de Arriola, daughter of Juan Ramos de Arriola and Isabel Flores de Abrego. He married Mariana Gonzalez de Paredes, daughter of Juan Gonzalez and Maria de Olea Camacho.