He married Antonia Guillen.

Maria de Aguirre married Nicolas Martinez Guajardo.

Clara de Aguirre married Juan Martinez Guajardo.

Ynes de Aguirre married Joseph de Farias.

Juan de Aguirre Guillen married Maria Gonzalez de Paredes, Juana Cortinas de Acosta, Maria de Ayala Benavides.

Nicolas de Aguirre married Jacinta Gonzalez de Paredes.

Teresa de Aguirre married Miguel de Lizarras y Cuellar.

Margarita de Aguirre married Alonso Flores de Valdez.

Jacinto de Aguirre married Ildefonsa Davila.

Pedro de Aguirre was born circa 1640. He married Mariana Gonzalez de Paredes, Maria Ramos de Arriola.