He married Ursula Ines Catarina Navarro Rodriguez, daughter of Juan Navarro and Maria Rodriguez de Sosa.

Catalina Martinez Guajardo. She married Juan Buentello Guerrero. She married Juan de Guzman. She married Marcos Alonso de la Garza y Arcon, son of Marcos Alonso de la Garza y Arcon and Juana Treviño Quintanilla.

Ignacio Martinez Guajardo. He married Maria Juana Flores de Valdez Salazar (del Valle), daughter of Rodrigo Flores de Valdez Carballo and Maria Isabel de Salazar y Treviño.

Juan Martinez Guajardo. He married Isabel Flores de Valdez, daughter of Rodrigo Flores de Valdez Carballo and Maria Isabel de Salazar y Treviño in 1622.

Francisca Martinez Guajardo. She married Domingo de la Fuente.

Maria Ines Rodriguez Martinez Guajardo, born 1585. She married Pedro de la Garza Falcon Treviño, son of Marcos Alonso de la Garza y Arcon and Juana Treviño Quintanilla in 1610. Her husband died on 8 Feb 1639 in Salinas Victoria. He was 50 years old.

Isabel Martinez Guajardo, born 1606. She married Francisco Baez de Benavides Lopez, son of Gonzalo Baez de Benavides and Martha Lopez in 1625. She died on 25 Jul 1693 in Monterrey. She was 87 years old. Her husband died in 1666 in Monterrey. He was 72 years old.

Lorenzo Martinez Guajardo, born 1610. He married Yldefonsa Flores de Valdez, daughter of Rodrigo Flores de Valdez Carballo and Maria Isabel de Salazar y Treviño.