He married Ursula Ines Catarina Navarro Rodriguez.

Catalina Martinez Guajardo married Marcos Alonso de la Garza y Arcon, Juan Buentello Guerrero, Juan de Guzman.

Ignacio Martinez Guajardo married Maria Juana Flores de Valdez Salazar (del Valle).

Juan Martinez Guajardo married Isabel Flores de Valdez.

Francisca Martinez Guajardo married Domingo de la Fuente.

Maria Ines Rodriguez Martinez Guajardo was born circa 1585. She married Pedro de la Garza Falcon Treviño.

Isabel Martinez Guajardo was born circa 1606. She married Francisco Baez de Benavides Lopez.

Lorenzo Martinez Guajardo was born circa 1610. He married Yldefonsa Flores de Valdez.