Nicolas Martinez Guajardo was the son of Juan Martinez Guajardo and Isabel Flores de Valdez.
He married Maria de Aguirre.
Maria Martinez Guajardo married Capt. Nicolas Ramos de Arriola.
Teodora Martinez Guajardo married Francisco Gonzalez de Paredes.
Antonio Guajardo married Maria de Villarreal.
Juan Guajardo de Aguirre married Maria Garcia de Morales.