His father was Juan Francisco Martinez Guajardo, and his mother was Ursula Ines Catarina Navarro Rodriguez.
He married Isabel Flores de Valdez, daughter of Rodrigo Flores de Valdez Carballo and Maria Isabel de Salazar y Treviño in 1622.
Catalina Martinez. She had a relationship with Joseph Ramon (de Morales), son of Luis Morales and Juana de Treviño Quintanilla y Salazar.
Nicolas Martinez Guajardo. He married Maria de Aguirre, daughter of Capt. Pedro de Aguirre and Antonia Guillen.
Juan Martinez Guajardo. He married Clara de Aguirre, daughter of Capt. Pedro de Aguirre and Antonia Guillen.
Alonso Martinez Guajardo. In 1687, he requested a dispensation to marry Juana de la Cadena Vergara. He married Phelipa Muñoz y Serrano de Pamplona.
Isabel Flores Guajardo. She married Antonio Cortinas de Acosta.
Maria Guajardo. She married Bartolome de Cuellar.