He married Clara de Aguirre, daughter of Capt. Pedro de Aguirre and Antonia Guillen.
Antonia Martinez Guajardo. On 23 Sep 1686, she requested a dispensation to marry Jacinto Ramos de Arriola.
Maria Martinez Guajardo. She married Cristobal Morales.
Ildefonsa Martinez Guajardo. She married Cristobal de Villarreal.
Miguel Guajardo. He married Petronila Montes de Oca.
Juana Martinez Guajardo. She married Francisco de Gongora, son of Sgt Maj Antonio de Gongora and Ana Gonzalez.
Francisca Martinez Guajardo. She married Antonio de Cepeda, son of Esteban de Cepeda and Isabel Camacho.
Isabel Guajardo. She married Andres Gonzalez, son of Bartolome Gonzalez and Isabel Dominguez y Gomez de Esquivel.