His father was Capt. Pedro de Aguirre, and his mother was Antonia Guillen.
He married Maria Gonzalez de Paredes, daughter of Juan Gonzalez and Maria de Olea Camacho.
He married Juana Cortinas de Acosta, daughter of Antonio Cortinas de Acosta and Isabel Martinez. It was his second marriage.
In 1695, he requested a dispensation to marry Maria de Ayala Benavides. the bride was 45 years old. It was his third marriage, and her second marriage. Dispensation source: Guerra, et. al., Index to the Marriage Investigations of the Diocese of Guadalajara, p.137. His wife died on 16 Oct 1735 in Saltillo. She was 85 years old.
Juan de Aguirre. He married Juana Lobo Guerrero. He married Maria Davila, daughter of Joseph Davila.
Clara de Aguirre. She married Nicolas de Avila, son of Lorenzo Davila and Bernarda Flores Guajardo.
Maria Josefa de Aguirre. In 1704, she requested a dispensation to marry Pedro Martin Montes de Oca.
Antonia de Aguirre. She married Juan Galindo, son of Joseph Galindo and Luisa de Caliz on 23 Aug 1707 in Saltillo.