He was born circa 1610. His father was Juan Francisco Martinez Guajardo, and his mother was Ursula Ines Catarina Navarro Rodriguez.
He married Yldefonsa Flores de Valdez, daughter of Rodrigo Flores de Valdez Carballo and Maria Isabel de Salazar y Treviño.
Nicolas Martinez Guajardo. He married Micaela Guerra, daughter of Vicente Guerra Cañamar and Leonor de Morales. He married Isabel Mendez Tovar.
Teodora Martinez Guajardo. She married Juan de Abrego, son of Juan Martinez de Salazar and Isabel Gutierrez.
Bernarda Martinez Guajardo. She married Lorenzo Davila.
Leonarda Martinez Guajardo. She married Joseph de los Santos Coy, son of Pedro de los Santos Coy and Francisca de Morales.
Mariana Martinez Guajardo. She married Juan Gomez Mascorro.
Joseph Martinez Guajardo, born 1646. In 1667, he requested a dispensation to marry Nicolasa de la Garza de la Rocha.