He married Maria de la Garza Garcia, daughter of Capt. Francisco de la Garza Falcon and Juana Garcia Gutierrez.
He married Ines de Renteria, daughter of Jacinto Garcia de Sepulveda and Clara de Renteria. It was his second marriage.
He married Tomasa Flores. It was his third marriage.
He married Mariana Cortinas, daughter of Antonio Cortinas de Acosta and Isabel Martinez. It was his fourth marriage.
Maria de Villarreal. She married Francisco Cantu, son of Geronimo Cantu and Juliana de Treviño.
Joseph de Villarreal. He married Ines Cortinas de Acosta, daughter of Antonio Cortinas de Acosta and Isabel Martinez.
Beatriz de Villarreal. She married Geronimo Cantu del Rio y la Cerda, son of Geronimo Cantu and Juliana de Treviño.
Clara de Renteria. In 1685, she requested a dispensation to marry Miguel de la Garza.
Margarita de Renteria. She married Antonio Leal.
Tomasina de Villarreal. She married Nicolas de Treviño.
Francisco de Villarreal. In 1699, he requested a dispensation to marry Nicolasa de la Garza. He married Agustina de Treviño. He married Maria Catalina de la Garza.