He married Juliana de Treviño, daughter of Alonso Treviño de la Garza and Anastacia Gonzalez Hidalgo.

Maria Josefa Cantu. She married Diego Hinojosa Montaño, son of Vitali de Hinojosa and Maria Montano.

Fernando Cantu. He married Gertrudis de la Garza, daughter of Lazaro de la Garza Falcon and Petronila de Montemayor. He married Antonia Ortiz. He married Antonia Ramirez in 1684. He married Maria de Villarreal, daughter of Francisco de Villarreal and Ursula de Izaguirre.

Geronimo Cantu. He married Beatriz de Villarreal, daughter of Diego de Villarreal and Maria de la Garza.

Francisco Cantu. He married Maria de Villarreal, daughter of Diego de Villarreal and Maria de la Garza.

Micaela Cantu. She married Bernabe Rodriguez de Carvajal, son of Alonso Rodriguez de Carbajal and Luisa de las Casas.