Her father was Diego de Villarreal, and her mother was Maria de la Garza.
She married Geronimo Cantu del Rio y la Cerda, son of Geronimo Cantu and Juliana de Treviño.
Francisco Cantu. In 1708, he requested a dispensation to marry Maria Josefa Manuela de la Garza, daughter of Salvador de la Garza and Juana Gutierrez de Castro. He had a relationship with Beatriz de Villarreal, daughter of Francisco de Villarreal and Ursula de Saldivar [Urrutia].