He married Beatriz de Villarreal, daughter of Diego de Villarreal and Maria de la Garza.
Antonia Cantu. In 1693, she requested a dispensation to marry Isidro de la Garza.
Maria Cantu. She married Miguel Flores de Abrego.
Maria Josefa Cantu. She married Nicolas de Saldivar. She married Marcos de Villanueva. She married Juan Antonio Valdez.
Ana Maria Cantu. She married Bartolome Jimenez de Cisneros.
Margarita Cantu. She married Juan Antonio Flores.
Francisco Cantu. In 1708, he requested a dispensation to marry Maria Josefa Manuela de la Garza. He had a relationship with Beatriz de Villarreal, daughter of Francisco de Villarreal and Ursula de Saldivar [Urrutia].
Cristobal Cantu. He married Ana Maria Cardenas, daughter of Joseph de Cardenas and Josefa Gonzalez. He married Maria Gertrudis de Villarreal.