He married Beatriz de las Casas.

Cristobal de Villarreal married Micaela de Treviño, Ildefonsa Martinez Guajardo.

Juan de Villarreal married Juana de la Garza.

Juan Bautista de Villarreal married Luisa de la Garza.

Francisco de Villarreal married Ursula de Isaguirre (Urrutia).

Diego de Villarreal married Maria de la Garza Garcia, Ines de Renteria, Tomasa Flores, Mariana Cortinas.

Luisa de las Casas married Alonso Rodriguez de Carvajal.

Bernabe de Villarreal was born circa 1635. He married Maria Isabel de la Garza.