He married Gertrudis Ramirez, daughter of Jose Eugenio Ramirez Hinojosa and Maria Rita de la Garza Falcon. Her father owned Revilla 16 grant, Zapata County, Revilla 14 grant, Zapata County, Revilla 15 grant, Zapata County, Texas, Revilla 17 grant, Zapata County.
In 1852, he applied for confirmation Mier 55 from the State of Texas. Francisco Izaguirre was Juan Pantaleon Izaguirre's grandson.