His father was Jose Manuel Izaguirre, and his mother was Dorotea Gonzalez.
He married Gertrudis Ramirez, daughter of Jose Eugenio Ramirez Hinojosa and Maria Rita de la Garza Falcon. Her father owned land in Porción 16, Revilla, Zapata County, Porción 14, Revilla, Zapata County, Porción 15, Revilla, Zapata County, Texas, Porción 17, Revilla, Zapata County.
In 1852, he applied for confirmation Mier 55 from the State of Texas. Francisco Izaguirre was Juan Pantaleon Izaguirre's grandson.