His father was Nicolas Martinez Guajardo, and his mother was Micaela Guerra.
He married Maria Baez Treviño, daughter of Gov Gen Francisco Baez de Treviño and Catalina de Treviño y Maya.
Domingo Miguel Guajardo. He married Maria Josefa Caballero , daughter of Juan Caballero de los Olivos and Margarita de la Garza Montemayor. In 1729, he requested a dispensation to marry Anastacia de la Garza. In 1733, he requested a dispensation to marry Leonor Gomez de Castro.
Joaquin Guajardo. He married Gertrudis Hurtado de Mendoza.