He married Maria Nicolasa Treviño, daughter of Santiago de Treviño and Leonor de la Garza.

Maria Catarina Gomez de Castro. She married Blas de la Garza Falcon, son of Gov. Gen Blas de la Garza Falcon and Beatriz de Villarreal. Her husband died in 1767. He was 55 years old.

Leonor Gomez de Castro. In 1733, she requested a dispensation to marry Domingo Miguel Guajardo, son of Pedro Guajardo and Maria Baez Treviño.

Maria Petra Gomez de Castro, born in Cerralvo. She married Salvador Lozano, son of Alferez Nicolas Lozano and Juana de la Garza.