Domingo Miguel Guajardo was the son of Pedro Guajardo and Maria Baez Treviño.
He married Maria Josefa Caballero .
He requested a dispensation to marry Anastacia de la Garza in 1729. Dispensation source: Guerra et al., Index to the Marriage Investigations of the Diocese of Guadalajara, p.254 (258).
He requested a dispensation to marry Leonor Gomez de Castro in 1733. Dispensation source: Guerra et al., Index to the Marriage Investigations of the Diocese of Guadalajara, p.261.