He was born circa 1779. His father was Juan Pantaleon Izaguirre, and his mother was Maria Gertrudis Vela. His father owned Mier 55 grant, Starr County, Mier 56 grant.
He married Refugio Ramirez, daughter of Jose Luis Ramirez Hinojosa and Basilia Martinez. It was her second marriage. Her father owned Revilla 5 grant, Zapata County, Texas. Her mother owned Revilla 5 grant, Zapata County, Texas.
In 1782, he lived in Las Animas in household number 96. The church census recorded that he was a young child, español, and 3 years old. His household included 9 people:
Don Juan Pantaleon Izaguirre, married, español, age 60.
Gertrudis Vela, married, española, age 30.
Maria Rita Izaguirre, an unmarried girl, española, age 19.
Maria Antonia de la Encarnacion Izaguirre, an unmarried girl, española, age 14.
Maria Norberta Izaguirre, an unmarried girl, española, age 12.
Jose Manuel Izaguirre, a child, español, age 11.
Maria Luisa Izaguirre, a child, española, age 8.
Maria Manuela Izaguirre, a young child, española, age 5.
Jose Rafael Izaguirre, a young child, español, age 3.