He was born circa 1779. His father was Juan Pantaleon Izaguirre, and his mother was Maria Gertrudis Vela. His father owned land in Porción 55, Mier, Starr County, Porción 56, Mier. In 1782, he lived in Las Animas in household number 96. The church census recorded that he was a young child, español, and 3 years old. His household included 9 people.
He married Refugio Ramirez, daughter of Jose Luis Ramirez Hinojosa and Basilia Martinez. It was her second marriage. Her father owned land in Porción 5, Revilla, Zapata County, Texas. Her mother owned land in Porción 5, Revilla, Zapata County, Texas.