His father was Cayetano de Ayala, and his mother was Josefa de Treviño.
He married Clara Maria Guerra, daughter of Juan Guerra Cañamar and Juana Flores de Abrego.
Maria Guadalupe de Ayala. She married Pedro Jose Gil Saldaña, son of Francisco Saldaña and Maria Ygnes de Peña on 10 Jan 1781 in Monterrey. Her husband died on 7 Nov 1809 in Monterrey. He was 53 years old.
Josefa de Ayala. She married Ramon Guajardo, son of Joaquin Guajardo and Gertrudis Hurtado de Mendoza on 22 Apr 1775 in Monterrey.