His father was Joaquin Guajardo, and his mother was Gertrudis Hurtado de Mendoza.
He married Josefa Ayala, daughter of Pedro Leonicio de Ayala and Clara Maria Guerra on 22 Apr 1775 in Monterrey. Marriage source: link.
Maria Josefa Guajardo, born 1792. She married Pedro Saldaña, son of Francisco Saldaña and Maria Ygnes de Peña on 5 May 1808 in Monterrey. Her husband died on 7 Nov 1809 in Monterrey. He was 53 years old.