He married Leonor Gutierrez, daughter of Juan Martinez de Salazar and Isabel Gutierrez.

Ana de Arispe. She married Diego Garcia, son of Lorenzo Garcia and Leonor Abrego Gutierrez.

Juan de Arispe. He married Ana de Lizarras y Cuellar, daughter of Bartolome de Cuellar and Maria Guajardo.

Ysabel de Arispe. She married Andres de los Reyes.

Martin de Arispe. He married Antonia Morales, daughter of Rodrigo Morales.