He was born in Salinas. His father was Bartolome Cisneros, and his mother was Maria Mariana Villegas.
He married Maria Antonia Guajardo, daughter of Tomas Guajardo and Maria Ignacia Villarreal. She owned Camargo 79 (tract).
Jose Antonio Cisneros. On 3 Feb 1781, he requested a dispensation to marry Ana Maria Perez in Camargo.
In 1767, as a primitivo poblador, he was granted Camargo 79 by the King of Spain.
He left Camargo 79 to Maria Antonia Guajardo, the widow of the original grantee.