He was born circa 1567. His father was Baltazar Castaño de Sosa, and his mother was Inez Rodriguez.
He married Sebastiana de Treviño, daughter of Juan de Farias and Maria Ana de Treviño Quintanilla.
Maria Rodriguez. She married Gonzalo Fernandez de Castro, son of Juan Fernandez de Castro and Mayor de Renteria.
Monica Rodriguez Treviño. She married Miguel de Montemayor, son of Alberto del Canto and Estefana de Montemayor y Porcallo. Her husband He died in Monterrey.
Andrea Rodriguez. She married Fernan Blas Perez.