His father was Diego de Ayala Treviño, and his mother was Ana de Ovalle.
He married Inez Rodriguez de Montemayor, daughter of Miguel de Montemayor and Monica Rodriguez Treviño. His wife died on 12 Apr 1712 in Monterrey.
Diego de Ayala. He married Nicolasa Garcia Davila, daughter of Pedro Garcia de Avila and Margarita Cavazos de la Garza. He died on 23 Mar 1714 in Monterrey.
Maria de Ayala. She married Ignacio de Tijerina.
Joseph de Ayala. In 1693, he requested a dispensation to marry Isabel de Ochoa.