Diego de Ayala was the son of Diego de Ayala y Ovalle and Inez Rodriguez de Montemayor.
He married Nicolasa Garcia Davila.
Maria de Ayala married Teodoro de la Garza Falcon, Antonio Joseph Ximenez.
Rosa Quiteria de Ayala married Francisco Miguel Davila.
Ana Josefa de Ayala was baptized on 29 Mar 1704 in Monterrey. She married Jose Francisco de Saldaña.