He was born circa 1667. His father was Francisco Perez de Escamilla, and his mother was Leonor de Ayala.
He married Luisa de Ochoa, daughter of Nicolas Ochoa de Elejalde and Maria Isabel de la Garza Gonzalez on 10 Apr 1684 in Monterrey. He was 17 years old.
Juana de Escamilla. In 1735, she requested a dispensation to marry Joseph Valentin de la Garza.
Francisco de Escamilla. He married Luisa Rodriguez, daughter of Alonso Rodriguez and Margarita de la Garza.
Joseph Antonio de Escamilla. He married Maria Margarita de Abrego, daughter of Joseph de Abrego and Polonia Flores.