Joseph de Escamilla was born circa 1667, the son of Francisco Perez de Escamilla and Leonor de Ayala.
He married Luisa de Ochoa on 10 Apr 1684 in Monterrey.
Juana de Escamilla married Joseph Valentin de la Garza.
Francisco de Escamilla married Luisa Rodriguez.
Joseph Antonio de Escamilla married Maria Margarita de Abrego.