Francisco Perez de Escamilla was born circa 1640, the son of Francisco Perez de Escamilla.
He married Leonor de Ayala.
Joaquin de Escamilla was born circa 1663. He married Maria Teresa de Guzman.
Nicolasa de Escamilla was born circa 1666. She married Juan de Arellano, Juan de Treviño.
Joseph de Escamilla was born circa 1667. He married Luisa de Ochoa.
Francisco Perez de Escamilla was born circa 1670. He married Isabel Gonzalez Hidalgo.