He married Leonor de Ayala, daughter of Francisco de Treviño and Bernardina de Abrego.
Joaquin de Escamilla, born 1663. He married Maria Teresa de Guzman, daughter of Juan de Guzman and Juana de Velastigui on 26 Jan 1689 in Monterrey.
Nicolasa de Escamilla, born 1666. She married Juan de Treviño, son of Joseph de Treviño and Maria Ana Navarro on 22 May 1679 in Monterrey. She requested a dispensation to marry Juan de Arellano.
Joseph de Escamilla, born 1667. He married Luisa de Ochoa, daughter of Nicolas Ochoa de Elejalde and Maria Isabel de la Garza Gonzalez on 10 Apr 1684 in Monterrey.
Francisco Perez de Escamilla, born 1670. He requested a dispensation to marry Isabel Gonzalez Hidalgo. They were married on 22 Nov 1694 in Monterrey.
Founder of Cadereyta (1637) Rancho del Ancon, near Monterrey