He married Mariana de la Garza Falcon on 20 Feb 1735 in Monclova.Their padrinos were Jose Joaquin de Urrutia y Ecay Muzquiz and Maria Candelaria de la Garza Falcon. The witnesses were Pedro Garcia de Rivera and Ignacio Guerra. The groom was absent and was married by proxy by Capitan don Miguel de la Garza, on 30 Oct 1734. Marriage source: (Link to original).

Juana Antonia Martina Ecay Muzquiz was baptized on 22 Nov 1735 in Monclova.

Juana Javiera Narcisa Ecay Muzquiz was baptized on 8 Nov 1739 in Monclova.

Maria Guadalupe Antonia Ecay Muzquiz was baptized on 12 Dec 1740 in Santa Rosa de Lima. She married Juan Nepomuceno de Alderete.

Joseph Antonio Ecay Muzquiz was baptized on 6 Jan 1742 in Santa Rosa de Lima.

Blas Maria Ecay Muzquiz was baptized on 3 May 1744 in Santa Rosa de Lima. He married Juana Francisca Urrutia.

Miguel Francisco Ecay Muzquiz was baptized on 26 Oct 1746 in Santa Rosa de Lima. He married Maria Gertrudis de Alderete.

Jose Maria Ecay Muzquiz was baptized on 17 Mar 1748 in Santa Rosa de Lima.

Francisco Javier Ecay Muzquiz was baptized on 19 Feb 1750 in Santa Rosa de Lima.

Maria Gertrudis de la Luz Ecay Muzquiz was baptized on 27 Sep 1752 in Santa Rosa de Lima.

Mariano Catalino Ecay Muzquiz was baptized on 25 Nov 1758 in Santa Rosa de Lima.