He married Maria Teresa Caballero, daughter of Sgt. Maj. Lucas Caballero de los Olivos and Margarita Rodriguez de Montemayor.

Domingo Mireles. In 1727, he requested a dispensation to marry Maria Guadalupe Perez de Moya, daughter of Juan Perez de Moya and Josefa de Treviño.

Maria de Zaragoza Mireles. She married Juan Saenz.

Maria Gertrudis Mireles. In 1725, she requested a dispensation to marry Joseph de la Garza, son of Manuel de la Garza and Maria Cavazos Fernandez de Castro.