Jose Antonio Canales was the son of Francisco Javier Canales and Maria Gertrudis Salinas.
He married Maria Rita Peña.
Josefa Canales married Agapito Ramirez.
In 1834 he settled at La Zacatosa.
In 1836 he was granted La Zacatosa by the State of Tamaulipas.
In 1852, as a great-grandson of the original grantee, he applied for confirmation of Mier 61 from the State of Texas.
In 1838 he temporarily abandoned La Zacatosa. He did not reside permanently on the tract after 1838 due to attacks by hostile Indians. See GLO abstract S-167
In 1852 he applied for confirmation of La Zacatosa from the State of Texas.