He married Josefa Flores de Valdez, daughter of Juan Flores de Valdez and Josefa de Hoyos de la Garza.
Gertrudis Flores de Abrego. On 15 Jun 1734, she requested a dispensation to marry Juan Antonio de Yrigoyen.
Antonia Flores de Abrego. On 29 Jul 1750, she requested a dispensation to marry Joseph de Cepeda.
Francisco Flores de Abrego. He married Francisca Travieso.
Juan Jose Flores de Abrego, born 1715. In Apr 1736, he requested a dispensation to marry Nicolasa Davila in Saltillo. They were married on 6 Aug 1736 in Saltillo. He married Leonor Delgado on 3 Feb 1750 in San Fernando de Bexar.