He married Juana Garcia, daughter of Lorenzo Garcia and Maria Flores de Valdez (del Valle).
He married Bernarda de Herrera, daughter of Francisca de Herrera. It was his second marriage.
Margarita de Cepeda Caballero. She married Miguel Flores de Valdez, son of Diego Flores de Valdez and Maria de Abrego (Guillen).
Antonio de Cepeda. He married Isabel Garcia, daughter of Lorenzo Garcia and Maria Flores de Valdez (del Valle).
Miguel de Cepeda. He married Ana de Avila, daughter of Nicolas de Avila and Clara de Aguirre.
Josefa de Cepeda. She married Cristobal Flores, son of Maria de Alvaro.
Francisca Javiera de Cepeda. In 1707, she requested a dispensation to marry Francisco Ramon in Saltillo .
Rodrigo de Cepeda. He married Josepha de Morales. He married Geronima de Morales, daughter of Andres de Morales.
Joseph de Cepeda. On 29 Jul 1750, he requested a dispensation to marry Antonia Flores de Abrego.
Maria de Cepeda. She married Felipe Galindo, son of Juan Galindo and Antonia de Aguirre.