His father was Rodrigo Flores de Valdez Carballo, and his mother was Maria Isabel de Salazar y Treviño.
He married Maria Magdalena Maldonado, daughter of Pedro Maldonado.
He married Maria Gomez, daughter of Juan Gomez Mascorro and Mariana Martinez. It was his second marriage.
Juan Flores de Valdez. He married Teresa Colchada.
Beatriz Flores de Valdez. She married Nicolas Cabello, son of Manuel Cabello and Maria de Farias.
Pedro Flores de Valdez. He married Maria del Toro.
Nicolasa Flores de Valdez. She married Juan de Montemayor.
Regina Flores de Valdez. She married Salvador de Farias.
Maria Gomez married to Miguel Flores Jr?