His father was Juan Bautista de Villarreal, and his mother was Luisa de la Garza.
He married Gertrudis de Treviño, daughter of Nicolas de Treviño and Maria de Renteria.
Maria Nicolasa de Villarreal. On 28 Dec 1730, she requested a dispensation to marry Javier Benavides, son of Juan de Benavides and Clara Maria Guiterrez in Real de Sabinas due to 3rd, 4th, and 4th degree cosanguinity.