His father was Francisco Botello de Morales, and his mother was Juana de la Garza Martinez Guajardo.
He married Sebastiana de la Paz.
He married Josefa Gonzalez de Ochoa, daughter of Andres Gonzalez Quintanilla and Juana de Ochoa Ruelas on 1 Jul 1689 in Monterrey. It was his second marriage.
Ines (Elena) Botello de Morales. She requested a dispensation to marry Francisco Sanchez de la Barrera.
Catarina Javiera Botello de Morales. She married Joseph Cipriano Zambrano Rendon, son of Nicolas Zambrano Tresalvo and Maria de Rendon on 12 May 1726 in Monterrey.
Margarita Botello de Morales. She married Francisco de Mier Noriega on 3 Dec 1713 in Monterrey.
Juana Javiera Botello de Morales. She requested a dispensation to marry Joseph Antonio de Treviño. They were married on 8 Dec 1722 in Monterrey.
Maria Josefa Botello de Morales, baptized 7 Oct 1693 in Santa Catarina. She requested a dispensation to marry Cristobal Garcia de Quintanilla. They were married on 1 Apr 1707 in Monterrey.
Francisco Javier Botello de Morales, baptized 15 Sep 1714 in Monterrey. He married Petra Rosalia Martinez Benavides, daughter of Andres Martinez and Maria Lugarda de Benavides on 26 Oct 1735 in Monterrey.