His father was Nicolas de la Cerna y Contreras, and his mother was Leonor de la Garza.
He married Juana Rosa Ruiz.
He married Margarita de las Casas, daughter of Marcos de las Casas and Gertrudis de la Vega on 30 Sep 1669 in Monterrey. It was his second marriage.
Nicolas Antonio Cerna. In 1731, he requested a dispensation to marry Margarita de Montemayor.
Maria de la Contreras y Peralta. She married Joseph Gonzalez Hidalgo, son of Bernabe Gonzalez Hidalgo and Leonor Garcia Gutierrez.
Francisco de la Cerna. He married Clara Garcia Davila, daughter of Pedro Garcia de Avila and Margarita Cavazos de la Garza.
Maria Gertrudis de la Cerna. She married Nicolas de Quintanilla, son of Nicolas de Quintanilla and Beatriz Fernandez de Tijerina.
Feliz de la Cerna. In 1703, he requested a dispensation to marry Maria de la Garza Falcon Gonzalez.
Miguel de la Cerna. He married Ana Maria Gonzalez Hidalgo.