He was born in Mexico City. His father was Francisco de la Serna, and his mother was Catalina de Alarcon.
He married Leonor de la Garza, daughter of Capt. Blas Maria de la Garza Falcon Treviño and Beatriz Gonzalez Hidalgo Navarro.
Nicolas de la Cerna y Alcarcon. He married Juana Rosa Ruiz. He married Margarita de las Casas, daughter of Marcos de las Casas and Gertrudis de la Vega on 30 Sep 1669 in Monterrey.
Joseph de la Cerna. He married Maria Botello, daughter of Francisco Botello de Morales and Juana de la Garza Martinez Guajardo.