He married Isabel de la Fuente (del Valle), daughter of Joseph de la Fuente and Luisa Flores de Valdez.
In 1693, he requested a dispensation to marry Maria Menchaca in Monclova. He was 43 years old. It was his second marriage. Dispensation source: Guerra, et. al., Index to the Marriage Investigations of the Diocese of Guadalajara, 6-32, p.32.
Rosa Garcia Flores. She married Nicolas Ramon, son of Diego Ramon and Feliciana Camacho.
Juana Garcia Flores. In 1695, she requested a dispensation to marry Joseph Ramon in Monclova. They were married on 17 Jul 1710 in Cerralvo.
Maria Luisa Garcia Flores. She married Andres Ramon Camacho, son of Diego Ramon and Feliciana Camacho.
Antonia Garcia. She married ___ Charles.