Her father was Miguel Domingo Villarreal, and her mother was Josefa Guajardo.
She married Ildefonso de la Garza, son of Antonio de la Garza and Margarita de la Serna.
In 1767, as the wife of a soldier, she was granted Camargo 75 by the King of Spain. Her husband was Sgt Lt Yldefonso de la Garza, who was absent in the service of the King.