She was born circa 1742. Her father was Salvador Vela, and her mother was Maria Agueda Longoria. Her father owned Porción 90, Camargo. In 1750, she lived in Camargo. The census recorded that she was the daughter of a settler, española, and 8 years old. Her household had 10 people, and they received government aid to move to the colony.
She married Jose Gregorio Villarreal, son of Jose Antonio Villarreal and Maria Catarina Hinojosa.
Marcos Villarreal. He married Juana Josefa Vela, daughter of Nicolas Vela and Maria Regina Garcia. He owned Porción 7, Camargo.