He married Juana Francisca Guerra Ayala on 6 Nov 1787 in Monterrey.

Jose Francisco Anastacio Saldaña was baptized on 1 Feb 1789 in Monterrey. He married Maria Julia de la Peña.

Jose Fernando Saldaña was baptized on 2 Jun 1791 in Monterrey. He married Maria de la Soledad Lozano.

Jose de los Santos Saldaña was baptized on 23 Apr 1803 in Monterrey. He married Maria Dolores Fernandez.

Jose Antonio Esmeregildo Saldaña was baptized on 23 Apr 1803 in Monterrey. He married Maria de los Angeles Ramirez, Felipa Ramirez.

Francisco Florentino Saldaña was baptized on 19 Oct 1805 in Monterrey. He married Maria Rosaura Ayala.

Maria de la Soledad Saldaña was baptized on 15 Apr 1810 in Monterrey.

Jose Ignacio Merced Saldaña was baptized on 12 Mar 1815 in Monterrey. He married Maria Antonia Juliana Lozano.