He was born circa 1751. His father was Juan Antonio Ramos, and his mother was Ana Maria Anzaldua. His father owned Mier 42 grant.
He married Maria Antonia Zapopa Resendez, daughter of Antonio Resendez and Maria Candelaria Lopez on 2 Aug 1777 in Mier. He was 26 years old, and the bride was 28 years old. Her father owned Mier 49 grant.
In 1782, he lived in Mier in household number 23. The church census recorded that he was married, español, and 30 years old. His household included 2 people:
Manuel Antonio Ramos, married, español, age 30.
Maria Zapopa Resendez, married, española, age 33.