He was born circa 1641. His father was Sgt. Maj. Joseph Ramon (de Morales), and his mother was Catalina Martinez.
He married Maria de los Rios.
He married Feliciana Camacho, daughter of Andres Camacho and Juana Botello de Morales in 1676. He was 35 years old, and the bride was 16 years old. It was his second marriage, and her second marriage.
In 1674, he was a soldier with Francisco Elizondo's Expedition. In 1688, he accompanied Governor Alonso De Leon into Texas. Between March 1691 to June 1698, he served as the third governor of Coahuila. On December 14, 1698, Diego Ramon and Fray Cristobal Montes de Oca founded the mission San Francisco Xavier y Valle de San Cristobal, some forty leaugues northeast of Villa de Pilon (Monclova). On March 1, 1700, he founded the Mission San Fernando Solano. This mission would later be relocated and remembered today as the Alamo. From 1703, till his death, he was the Commandant of the Royal presidio of San Juan Bautista, Coahuila, Mexico. This presidio had been established in 1702.
He died on 10 Apr 1719 in San Juan Bautista. He was 78 years old.