Her father was Pedro Santiago de Hoyos, and her mother was Maria de la Garza de la Rocha.
In 1695, she requested a dispensation to marry Geronimo Rodriguez in Monclova. They were married in Monclova. Dispensation source: Guerra, et. al., Index to the Marriage Investigations of the Diocese of Guadalajara, p.39.
Juan Victor Rodriguez. In 1724, he requested a dispensation to marry Margarita de la Garza.