He married Maria de Jesus de la Garza, daughter of Lorenzo de la Garza and Maria Gonzalez Hidalgo.
In 1707, he requested a dispensation to marry Catarina Gonzalez. They were married in 1707. It was his second marriage. Dispensation source: Guerra, et. al., Index to the Marriage Investigations of the Diocese of Guadalajara, p.197.
Ana Josefa de la Garza. In 1748, she requested a dispensation to marry Salvador Gomez de Castro.
Miguel de la Garza. In 1728, he requested a dispensation to marry Josefa Gonzalez. In 1750, he requested a dispensation to marry Maria Josefa de Leon.
Joseph de la Garza. In 1735, he requested a dispensation to marry Margarita Leal de Leon.
Agustin Seferino de la Garza. In 1746, he requested a dispensation to marry Manuela Leal Guerra.
Maria Gertrudis de la Garza. She married Marcos Leal de Leon.
Catarina Theodora de la Garza. She married Juan Joseph de Tijerina.