His father was Alonso de Cardenas Pinillas, and his mother was Maria Guerra.
He married Petronila de Villarreal, daughter of Juan de Villarreal and Juana de la Garza.
Nicolasa de Cardenas. She married Nicolas de Villarreal, son of Nicolas de Villarreal and Margarita de Renteria in 1707.
Juan Antonio de Cardenas. He married Ana Maria Gonzalez de Ochoa, daughter of Nicolas Gonzalez de Ochoa and Nicolasa Flores.