He married Josepha de la Garza, daughter of Salvador de la Garza.
He married Antonia de Villarreal, daughter of Juan Antonio de Villarreal and Andrea de la Garza. It was his second marriage.
Maria Antonia de la Cerna y Alarcon. She married Juan de Elizondo, son of Pedro de Elizondo and Maria de la Garza.
Josepha Gertrudis de la Cerna. In 1745, she requested a dispensation to marry Joseph Luis de la Garza.