He married Juana de Treviño (de la Cerda), daughter of Gaspar de Treviño and Ana de la Cerda.

Joseph Cardenas. He married Maria Josefa Gonzalez de Paredes, daughter of Manuel Gonzalez de Paredes and Ana de Villarreal.

Marcela Cardenas. She married Lazaro Gonzalez de Paredes, son of Joseph Gonzalez de Paredes and Angela de la Garza.

Nicolas de Cardenas Pinillas. He married Gertrudis Flores de Abrego, daughter of Miguel Flores de Abrego and Micaela de la Garza Renteria.

Cristobal de Cardenas. He married Aldonsa Ramos, daughter of Juan Ramos and Aldonza Gonzalez.

Miguel de Cardenas. He married Maria Gutierrez, daughter of Juan Gutierrez and Josefa Gil de Cardenas.

Juan de Cardenas Pinillas. He married Maria Rosa Rodriguez de Quiroga, daughter of Antonio Rodriguez de Quiroga and Juana de la Garza Renteria.

Felipa de Cardenas Pinillas. She married Joseph de Aguirre.