Jose Manuel Lopez de Jaen was born circa 1740, the son of Francisco Lopez de Jaen and Maria Agustina Longoria.
He married Maria Josefa Vela.
Josefa Lopez married Nicolas Villarreal.
In 1767, as the son of a primitivo poblador, he was granted Camargo 14 by the King of Spain. Manuel Lopez refused to take possession of this porcion, so it was assigned to Nuñez. The title was granted to the descendants of Miguel Lopez in 1849.